県立広島大学 生物資源科学部（庄原キャンパス）

2025年
1)Saitoh Y*, Kanawa S, Nohara T, Yamaguchi R, Wakita A, Ikeda C, Hamada H. Resveratrol polysaccharide is less cytotoxicity and inhibits UVA-, UVB-, and tertiary-butyl hydroperoxide-induced injury in human keratinocytes. Naunyn Schmiedebergs Arch Pharmacol. 2025, 398(6):7377-7387. doi: 10.1007/s00210-024-03749-6.

2)Saitoh Y*, Takeda K, Okawachi K, Tanimura Y. High dose of ascorbic acid induces selective cell growth inhibition and cell death in human gastric signet-ring cell carcinoma-derived NUGC-4 cells. Biochim Biophys Acta Gen Subj. 2025, 1869(2):130738. https://doi.org/10.1016/j.bbagen.2024.130566


2024年
1)Aoshima H*, Mizuno R, Iwatsu Y, Onishi S, Hyodo S, Ibuki R, Kawagishi H, Saitoh Y. Inhibitory effect of 2-Aza-8-oxohypoxanthine on tyrosinase activity and melanin production. Cosmetics 2024, 11(2), 43. https://doi.org/10.3390/cosmetics11020043


2023年
1)Saitoh Y, Takata Y, Miwa N, Hydrogen-nano-bubble-rich water in bucket/bathtub improves intractable skin roughness. Hydrogen, 2023, 4(3):456-473. https://www.mdpi.com/2673-4141/4/3/31#


2022年
1) Saitoh Y*, Yonekura N, Matsuoka D, Matsumoto A. Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells. Mol Cell Biochem. 2022, 477(1):99-104. https://doi.org/10.1007/s11010-021-04262-7 *Corresponding author


2021年
1) Saitoh Y*, Tanaka A, Hyodo S. Protective effects of polyvinylpyrrolidone-wrapped fullerene against nitric oxide/peroxynitrite-induced cellular injury in human skin keratinocytes. J Nanosci Nanotechnol. 2021, 21(9):4579-4585. doi: 10.1166/jnn.2021.19279.*Corresponding author

2) Kato S, Saitoh Y, Miwa N. Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen. Human Cell. 2021, 34(2):436-444. doi: 10.1007/s13577-020-00462-3.

3) Saitoh Y*, Kawasaki N, Eguchi N, Ikeshima M. Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4. Free Radic Res. 2021, 55(3):211-220. doi: 10.1080/10715762.2021.1902514.*Corresponding author

4)Saitoh Y*, Yamaguchi Y, Okada Y. Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes. Mol Cell Biochem. 2021, 476(10):3613-3622.  
doi: 10.1007/s11010-021-04189-z. *Corresponding author


2020年
1) Kato S, Saitoh Y, Miwa N. Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality.Human Cell 2020, 33(4):1294-1301. doi: 10.1007/s13577-020-00402-1.

2) Saitoh Y*, Umezaki T, Yonekura N, Nakawa A. Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and/or its intracellular reduction in HaCaT cells. Mol Cell Biochem. 2020,467(1-2):57-64. doi: 10.1007/s11010-020-03700-2..*Corresponding author (https://link.springer.com/article/10.1007/s11010-020-03700-2)
*Corresponding author


2019年
1) Asada R, Saitoh Y, Miwa N. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Med Gas Res. 2019 Apr-Jun;9(2):68-73.


2018年
1) Saitoh Y*, Comments to the article “Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media”. Free Radic Res. 2018, 52(9): 910-912. *Corresponding author

2) Saitoh Y*, Nakawa A, Tanabe T, Akiyama T. The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function. Mol Cell Biochem. 2018, 446(1-2):209-219. doi: 10.1007/s11010-018-3287-y. *Corresponding author

3) Hamada H, Shimoda K, Saitoh Y, Doi S, Fujitaka Y, Ono T, Hamada H, Araki M. Resveratrol oligosaccharides induces mRNA expression for SIRT. Natural product communications 2018, 13(4):455-456.

4)Tanaka Y, Saitoh Y, Miwa N. Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Medical Gas Research 2018, 8(1):12-18.


2017年
1)Ohwada R, Ozeki Y, Saitoh Y*. High-dose ascorbic acid induces carcinostatic effects through hydrogen peroxide and superoxide anion radical generation-induced cell death and growth arrest in human tongue carcinoma cells. Free Radic Res. 2017 Jul-Aug 51(7-8):684-692. doi: 10.1080/10715762.2017.1361533. (http://www.tandfonline.com/doi/full/10.1080/10715762.2017.1361533)*Corresponding author


2016年
1)Saitoh Y*, Ohta H, Hyoudou S. Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells. J Photochem Photobiol B. 2016, 163:22-29. *Corresponding author

2) Li Q, Tanaka Y, Saitoh Y, Miwa N. Effects of Platinum Nanocolloid in Combination with Gamma Irradiation on Normal Human Esophageal Epithelial Cells. J Nanosci Nanotechnol.2016 16:5345-5352.

3) Saitoh Y*, Ikeshima M, Kawasaki N, MasumotoA, Miwa N. Transient generation of hydrogen peroxide is responsible for carcinostatic effects of hydrogen combined with platinum nanocolloid, together with increases intracellular ROS, DNA cleavages, and proportion of G2/M-phase. Free Radical Res. 2016 Apr;50(4):385-95. doi: 10.3109/10715762.2015.1131823.
*Corresponding author


2015年
1) Saitoh Y*, Yoshimoto T, Kato S, Miwa N. Combined treatment with ascorbic acid and a capacitive-resistive electric transfer hyperthermic apparatus induces synergistically carcinostatic effects on Ehrlich ascites tumor cell. Exp Oncol. 2015, 37(2):94-99. *Corresponding author

2) Li Q, Tanaka Y, Saitoh Y, Tanaka H, Miwa N. Carcinostatic effects of platinum nanocolloid combined with gamma irradiation on human esophageal squamous cell carcinoma. Life Sci. 2015, 127:106-114. doi: 10.1016/j.lfs.2015.01.028.

3) Kato S, Kato Y, Shibata H, Saitoh Y, Miwa N. Repressive effects of oat extracts on intracellular lipid-droplet formation in adipocytes and a three-dimensional subcutaneous adipose tissue model. Materials science and engineering C. 2015, C49:269-273.

4) Ishikura H, Ono T, Oki S, Saito Y, Umei N, Tsumiyama W, Tasaka A, Aihara K, Sato Y, Matsumoto T, Otsuka A. Effect of stretch on improvement of muscular contractures in rats. J Phys Ther Sci. 2015, 27(9): 2821–2823. doi: 10.1589/jpts.27.2821


2014年
1) Kato S, Aoshima H, Saitoh Y, Miwa N. Fullerene-C60 derivatives prevent UV-irradiation/TiO2-induced cytotoxicity on keratinocytes and 3D-skin tissues through antioxidant actions. J Nanosci Nanotechnol. 2014, 14(5):3285-3291.

2) Asada R, Liao F, Saitoh Y, Miwa N. Photodynamic anti-cancer effects of fullerene [C₆₀]-PEG complex on fibrosarcomas preferentially over normal fibroblasts in terms of fullerene uptake and cytotoxicity. Mol Cell Biochem. 2014, 390(1-2):175-184.

3) Haeiwa H, Fujita T, Saitoh Y*, Miwa N. Oleic acid promotes adaptability against oxidative stress in 3T3-L1 cells through lipohormesis. Mol Cell Biochem. 2014, 386(1-2):73-83. DOI: 10.1007/s11010-013-1846-9. *Corresponding author


2013年
1) Saitoh Y, Morishita A, Mito S, Tsujiya T, Miwa N. Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts. Mol Cell Biochem. 2013, 380(1-2):129-141. doi: 10.1007/s11010-013-1666-y.

2) Kato S, Saitoh Y, Miwa N. Inhibitions by hydrogen-occluding silica microcluster to melanogenesis in human pigment cells and tyrosinase reaction. J Nanosci Nanotechnol. 2013, 13(1):52-59.

3)  Kato S, Saitoh Y, Miwa N. Repressive effects of a capacitive-resistive electric transfer (CRet) hyperthermic apparatus combined with provitamin C on intracellular lipid-droplets formation in adipocytes. Int J Hyperthermia. 2013, 29(1):30-37.


2012年 
1) Saitoh Y, Mizuno H, Xiao L, Hyoudou S, Kokubo K, Miwa N. Polyhydroxylated fullerene C₆₀(OH) ₄₄ suppresses intracellular lipid accumulation together with repression of intracellular superoxide anion radicals and subsequent PPARγ2 expression during spontaneous differentiation of OP9 preadipocytes into adipocytes. Mol Cell Biochem. 2012, 366(1-2): 191-200.

2) Kato S, Hokama R, Okayasu H, Saitoh Y, Iwai K, Miwa N. Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J. Nanosci. Nanotechnol. 2012, 12(5): 4019-4027.

3) Asada R, Kageyama K, Tanaka H, Kimura M, Saitoh Y, Miwa N. Carcinostatic effects of diverse ascorbate derivatives in comparison with aliphatic chain moiety structures: Promotion by combined hyperthermia and reduced cytotoxicity to normal cells. Oncol Lett. 2012, 3(5):1042-1046.

4) Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B. 2012, 106(1):24-33.

5) Asada R, Kageyama K, Tanaka H, Saitoh Y, Miwa N. Anti-tumor and anti-invasive effects of diverse musk-fragrant macrocyclic ketones and their enhancement by hyperthermia. Mol Med Report 2012, 5(1):148-152.


2011年
1) Xiao L, Aoshima H, Saitoh Y, Miwa N. Highly hydroxylated fullerene localizes at the cytoskeleton and inhibits oxidative stress in adipocytes and a subcutaneous adipose-tissue equivalent. Free Radic Biol Med. 2011, 51(7):1376-1389.

2) Kato S, Asada R, kageyama K, Saitoh Y, Miwa N. Anticancer effects of 6-O-palmitoyl-ascorbate combined with a capacitive-resistive electric transfer hyperthermic apparatus as compared with ascorbate in relation to ascorbyl radical generation. Cytotechnology　2011, 63(4):425-435.

3) Kato S, Aoshima H, Saitoh Y, Miwa N. Fullerene-C60 incorporated in liposome exerts persistent hydroxyl radical-scavenging activity and cytoprotection in UVA/B-irradiated keratinocytes. J Nanosci Nanotechnol. 2011, 11(5):3814-3823.

4) Liao F, Saitoh Y, Miwa N. Anticancer effects of fullerene [C₆₀] included in polyethylene glycol combined with visible light-irradiation through ROS generation and DNA fragmentation on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts. Oncol Res. 2011, 19(5):203-216.

5) Kato S, Matsui H, Saitoh Y, Miwa N. Fish collagen-containing drink is subcutaneously absorbed and attenuates the UVA-induced tissue-integrity destruction and DNA damages in 3D-human skin tissue model. J Funct Foods 2011, 3(1):50-55.

6) Saitoh Y, Miyanishi A, Mizuno H, Kato S, Aoshima H, Kokubo K, Miwa N. Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages. J Photochem Photobiol B. 2011, 102(1):69-76.

2010年

1) Asada R, Kageyama K, Tanaka H, Matsui H, Kimura M, Saitoh Y, Miwa N. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell

death. Oncol Rep. 2010, 24(6):1463-1470.

2)  Saitoh Y, Xiao L, Mizuno H, Kato S, Aoshima H, Taira H, Kokubo K, Miwa N. Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9

preadipocytes into adipocytes. Free Radical Research 2010, 44(9):1072-1081.

3)   Xiao L, Aoshima H, Saitoh Y, Miwa N.　 Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappa B. J Cell Biochem. 2010,

111(4):955-966.

4)   Kato S, Taira H, Aoshima H, Saitoh Y, Miwa N. Clinical Evaluation of Fullerene-C60 Dissolved in Squalane for Anti-Wrinkle Cosmetics. J Nanosci Nanotechnol. 2010, 10:6769-6774.

5)   Kato S, Aoshima H, Saitoh Y, Miwa N. Defensive effects of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal- induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model. J Biomed Nanotechnol. 2010, 6:52-58.

6)    Xiao L, Aoshima H, Saitoh Y, Miwa N. The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied

oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system. Biomaterials. 2010, 31:5976-5985.

7)    Watanabe S, Saitoh Y, Namba M, Miwa N. Administration with telomeric DNA telomere-like oligonucleotides induces enhancement of telomerase activity and resistance against oxidative stress in telomere reverse transcriptase gene-transfected human fibroblasts. Biomed Pharmacother. 2010, 64(8): 565-571.

8)    SaitohY, Harata Y, Mizuhashi F, Nakajima M, Miwa N. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicol Ind Health 2010, 26(4):203-216.

9)  Kato S, Kikuchi R, Aoshima H, Saitoh Y, Miwa N. Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60. J Photochem Photobiol B. 2010, 98(2):144-151.

10)  Kato S, Aoshima H, Saitoh Y, Miwa N. Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue. J Photochem Photobiol B. 2010, 98(1):99-105.

2009年

1)   Saitoh Y, Yumoto A, Miwa N.alpha-Tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia. Int J Oncol. 2009, 35(6):1277-1288. 

2)  SugimotoM, SaitohY, Ichihashi M, Miwa N. Suppressive effects of phosphorylated ascorbate on ultraviolet B radiation-induced DNA damage and differential expression of wild-type and mutated p53 tumor-suppressor gene in keratinocytes. Mol Med Rep. 2009, 2(6):917-922.

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